Sympatho-adrenal activation by chronic intermittent hypoxia
نویسندگان
چکیده
منابع مشابه
Sympatho-adrenal activation by chronic intermittent hypoxia.
Recurrent apnea with chronic intermittent hypoxia (CIH) is a major clinical problem in adult humans and infants born preterm. Patients with recurrent apnea exhibit heightened sympathetic activity as well as elevated plasma catecholamine levels, and these phenotypes are effectively recapitulated in rodent models of CIH. This article summarizes findings from studies addressing sympathetic activat...
متن کاملHIGHLIGHTED TOPIC Mechanisms of Sympathetic Regulation in Cardiovascular Disease Sympatho-adrenal activation by chronic intermittent hypoxia
Prabhakar NR, Kumar GK, Peng Y-J. Sympatho-adrenal activation by chronic intermittent hypoxia. J Appl Physiol 113: 1304–1310, 2012. First published June 21, 2012; doi:10.1152/japplphysiol.00444.2012.—Recurrent apnea with chronic intermittent hypoxia (CIH) is a major clinical problem in adult humans and infants born preterm. Patients with recurrent apnea exhibit heightened sympathetic activity a...
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RATIONALE Obstructive sleep apnea, a condition leading to chronic intermittent hypoxia (CIH), is associated with hyperlipidemia, atherosclerosis, and a high cardiovascular risk. A causal link between obstructive sleep apnea and atherosclerosis has not been established. OBJECTIVES The objective of the present study was to examine whether CIH may induce atherosclerosis in C57BL/6J mice. METHO...
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The development of sympathetic overactivity and hypertension in rats submitted to chronic intermittent hypoxia (CIH) involve alterations in the central mechanisms controlling respiratory and autonomic functions. Herein, we assessed whether CIH alters glutamatergic and/or purinergic signaling in the ventrolateral medulla (VLM), a region that encompasses the pre-sympathetic neurons and respirator...
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The autonomic nervous system, composed of sympathetic- and para-sympathetic neurons, plays essential roles in a variety of physiological functions including homeostasis and responses to external stimuli. We here present an overview of recent findings concerning how the sympathetic nervous system is formed during the early development, paying particular attention to the morphogenesis of those ti...
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ژورنال
عنوان ژورنال: Journal of Applied Physiology
سال: 2012
ISSN: 8750-7587,1522-1601
DOI: 10.1152/japplphysiol.00444.2012